Erythrocytes (Red Blood Cells)

Overview and Clinical Significance

Erythrocytes, commonly known as red blood cells (RBCs), are the most abundant blood cells, responsible for oxygen transport and carbon dioxide removal. They contain hemoglobin, a protein that binds oxygen and facilitates its delivery to tissues.

Clinical Significance

  • Oxygen Transport & Gas Exchange: RBCs carry oxygen from the lungs to tissues and return carbon dioxide for exhalation.
  • Bone Marrow Function & Erythropoiesis: RBCs are produced in the bone marrow, stimulated by erythropoietin, a hormone released by the kidneys.
  • Anemia & Blood Disorders: Low RBC count or hemoglobin levels indicate anemia, which can result from nutritional deficiencies, chronic disease, or bone marrow dysfunction.
  • Polycythemia & Blood Viscosity: Excess RBC production leads to polycythemia, increasing blood viscosity and cardiovascular risk.
  • Diagnostic Use: RBC indices, including mean corpuscular volume (MCV) and red cell distribution width (RDW), help assess anemia types and hematologic conditions.

Erythrocytes are essential for oxygen delivery, metabolic balance, and overall circulatory health, making them a key focus in hematology and clinical diagnostics.

Increasing +

Decreasing -

Polycythemia

  • Can be primary (such as polycythemia vera) or secondary (due to chronic hypoxia, high altitude, or lung diseases).

Dehydration

  • Hemoconcentration raises the relative red cell count.

Rare Autoimmune Processes

  • Some autoimmune conditions may trigger increased production as a reactive phenomenon.

Anemia

  • Due to nutritional deficiencies (iron, B12, folate), chronic disease, or blood loss.

Autoimmune Hemolysis

  • Antibodies target erythrocytes, leading to reduced counts.

Infections

  • Certain infections—or inflammatory autoimmune conditions such as lupus—can also cause anemia of chronic disease.

More Info

Related

Neonates

  • Newborns typically have higher hematocrits that normalize within the first weeks of life.

Children/Adolescents

  • Iron deficiency anemia is common, often related to growth spurts or dietary insufficiencies.

Adults/Elderly

  • Anemia is prevalent in chronic disease states.
  • Polycythemia increases in older individuals due to factors like smoking or lung conditions.

All Markers