Overview and Clinical Significance

Melanogene in urine refers to melanin-related metabolites that may indicate malignant melanoma, a type of skin cancer originating from melanocytes. While urine melanin tests are rarely used today, research suggests that fluorescence biomarkers in urine could serve as early detection tools for melanoma.

Clinical Significance

• Melanoma Detection & Disease Progression: Urine melanin tests were historically used to detect melanoma, particularly in cases where the cancer had spread to the liver.
• Fluorescence Biomarkers & Metabolic Indicators: Studies have identified fluorescent metabolites in urine that correlate with melanoma progression, including NAD(P)H, porphyrins, and lipofuscin.
• Limitations & Alternative Testing: While urine melanin tests are not commonly used, histopathological examination and imaging remain the gold standard for melanoma diagnosis.

Melanogene-related markers in urine are potential indicators of melanoma, influencing diagnostic research, disease monitoring, and early detection strategies.

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