Overview and Clinical Significance
Seromucoids are a group of glycoproteins found in plasma, characterized by their high carbohydrate content and solubility in perchloric acid. They play a role in inflammation, immune response, and tissue repair.
Clinical Significance
- Inflammatory & Immune Response: Seromucoid levels increase in infections, autoimmune diseases, and tissue trauma.
- Cancer Biomarker: Elevated seromucoid concentrations have been observed in various cancers, though their diagnostic specificity is debated.
- Liver & Kidney Function: Changes in seromucoid levels may indicate hepatic or renal dysfunction, particularly in jaundice differentiation.
- Post-Surgical & Stress Response: Seromucoid levels correlate with surgical trauma and physiological stress, making them useful in prognostic evaluations.
- Alternative Biomarkers: Some studies suggest replacing seromucoid assays with α1-acid glycoprotein testing, which offers greater precision.
Seromucoids are valuable in inflammatory, oncological, and metabolic assessments, though their clinical utility continues to be refined.
