Overview and Clinical Significance

Neopterin is a biomarker of immune activation, produced by macrophages in response to interferon-γ stimulation. It plays a role in inflammatory processes, cancer progression, and cardiovascular risk assessment.

Clinical Significance

• Cancer & Immune Response: Elevated neopterin levels are observed in various malignancies, including ovarian cancer, where it correlates with tumor burden and prognosis.
• Cardiovascular & Inflammatory Diseases: Neopterin is linked to coronary artery disease (CAD), with higher levels indicating atheromatous plaque vulnerability and increased cardiovascular risk.
• Immunotherapy & Prognostic Value: Increased neopterin concentrations reflect immune dysfunction, particularly in cancer patients undergoing immunotherapy.
• Diagnostic & Therapeutic Applications: Neopterin testing helps assess immune activation, cancer progression, and cardiovascular health.

Neopterin is a key biomarker for immune system activity, influencing cancer prognosis, cardiovascular risk, and inflammatory disease monitoring.

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