Overview and Clinical Significance

Thymidine kinase (TK) is a tumor proliferation marker involved in DNA synthesis and cell cycle regulation. It is widely studied in hematologic malignancies and solid tumors, aiding in cancer diagnosis, prognosis, and treatment monitoring.

Clinical Significance

• Cell Proliferation & Tumor Growth: TK is activated during the G1/S phase, correlating with tumor aggressiveness and progression.
• Hematologic Malignancies & Prognostic Value: Elevated TK levels are observed in non-Hodgkin’s lymphoma and leukemia, providing predictive insights into treatment response.
• Solid Tumors & Cancer Monitoring: TK expression has been studied in lung, breast, and colorectal cancers, with potential applications in early detection and therapeutic targeting.
• Diagnostic & Therapeutic Applications: TK testing helps assess tumor burden, relapse risk, and treatment efficacy, making it a valuable biomarker in oncology.

Thymidine kinase is a key regulator of tumor biology, influencing cancer progression, diagnostic accuracy, and therapeutic strategies.

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