Overview and Clinical Significance

Alpha-1-antichymotrypsin (AACT), also known as Alpha-1-aoraprotein (APR), is a serine protease inhibitor involved in inflammation, immune response, and tumor progression. It is primarily synthesized in the liver and secreted into the bloodstream, playing a role in acute-phase reactions and cancer biology.

Clinical Significance

• Tumor Progression & Prognostic Value: AACT is linked to tumor recurrence and survival outcomes, with altered expression observed in liver, pancreatic, and lung cancers.
• Inflammation & Immune Modulation: It regulates proteolysis and immune responses, influencing cancer progression and inflammatory diseases.
• Diagnostic & Therapeutic Applications: AACT may serve as a biomarker for tumor monitoring, aiding in diagnosis, prognosis, and potential therapeutic targeting.

AACT is a key regulator of tumor biology, influencing cancer progression, immune response, and diagnostic evaluations.

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