Overview and Clinical Significance
Immunoglobulin E (IgE) is an antibody primarily involved in allergic reactions and immune defense against parasites. It plays a crucial role in hypersensitivity responses, binding to mast cells and basophils, triggering the release of histamine and other inflammatory mediators.
Clinical Significance
- Allergic Reactions & Asthma: Elevated IgE levels are associated with hay fever, eczema, asthma, and anaphylaxis.
- Parasitic Infections: IgE helps combat helminth infections, enhancing immune responses against intestinal parasites.
- Autoimmune & Inflammatory Disorders: Abnormal IgE levels may indicate chronic inflammation, immunodeficiency, or hypersensitivity syndromes.
- Cancer & Hematologic Conditions: Some malignancies, including Hodgkin’s lymphoma, can lead to increased IgE levels.
- Diagnostic & Therapeutic Applications: IgE testing is used to diagnose allergies, monitor immune function, and assess hypersensitivity disorders.
IgE is a key regulator of immune responses, influencing allergic conditions, parasitic defense, and inflammatory pathways.
