Overview and Clinical Significance
Immunoglobulin G (IgG) is the most abundant antibody in the bloodstream, accounting for 75-80% of total serum immunoglobulins. It plays a crucial role in immune defense, pathogen neutralization, and long-term immunity.
Clinical Significance
- Infection Control & Immune Memory: IgG provides long-lasting immunity, recognizing and neutralizing bacteria, viruses, and toxins.
- Autoimmune & Inflammatory Disorders: Elevated IgG levels may indicate chronic inflammation, autoimmune diseases, or monoclonal gammopathies.
- Immunodeficiency & Susceptibility to Infections: Low IgG levels are linked to primary immunodeficiencies, recurrent infections, and protein-losing syndromes.
- Diagnostic & Therapeutic Applications: IgG testing helps assess immune function, chronic disease progression, and therapeutic responses.
IgG is a key regulator of immune defense, influencing infection resistance, autoimmune activity, and long-term immunity.
