High Properdin Levels

• Acute Infections – Bacterial infections may trigger increased properdin production to enhance immune response.
• Inflammatory Conditions – Chronic inflammatory or autoimmune diseases may lead to elevated properdin levels.
• Tissue Injury – Properdin can rise as part of the body's natural defense mechanism during trauma or stress.

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Low Properdin Levels

• Properdin Deficiency – A rare X-linked disorder that increases susceptibility to infections, particularly with Neisseria species (e.g., meningococcal disease).
• Immune Dysfunction – Lower properdin levels may indicate impaired complement activation, reducing the body's ability to fight bacterial infections.
• Chronic Illness – Some underlying health conditions may lead to naturally low properdin levels.

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Life-Phase Considerations for Properdin

• Children – Properdin deficiency poses a greater risk of bacterial infections, making early detection critical.
• Adults – Fluctuations occur depending on infection exposure, autoimmune activity, and systemic inflammation.
• Elderly – Age-related immune changes may alter complement function, affecting properdin levels.

Properdin’s role in immune defense makes it an important marker for complement system function and susceptibility to infections. Let me know if you’d like to explore how it interacts with other immune markers!

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