Overview and Clinical Significance
Immunoglobulin M (IgM) is the first antibody produced during an immune response, primarily found in the blood and lymphatic system. It plays a crucial role in early-stage immunity and pathogen neutralization.
Clinical Significance
- Infection Detection: Elevated IgM levels indicate recent or acute infections, helping in early-stage disease diagnosis.
- Autoimmune & Inflammatory Disorders: Abnormal IgM levels may signal chronic inflammation, autoimmune diseases, or monoclonal gammopathies.
- Immunodeficiency & Susceptibility to Infections: Low IgM levels are associated with immune deficiencies, increasing vulnerability to recurrent infections.
- Diagnostic & Therapeutic Applications: IgM testing is valuable for assessing immune health, monitoring disease progression, and guiding treatment decisions.
IgM is a key component of immune defense, crucial for infection control, immune response regulation, and early immune system activation.
