Overview and Clinical Significance

Serum uric acid is a metabolic byproduct of purine breakdown, primarily excreted by the kidneys. It plays a role in antioxidant defense, metabolic regulation, and disease risk assessment.

Clinical Significance

• Gout & Arthritis: Elevated uric acid levels can lead to gout, a painful inflammatory arthritis caused by urate crystal deposition in joints.
• Kidney Function & Urolithiasis: High uric acid concentrations may contribute to kidney stones, impairing renal function.
• Cardiovascular & Metabolic Health: Hyperuricemia is associated with hypertension, diabetes, and metabolic syndrome, influencing cardiovascular risk.
• Neurological & Cognitive Effects: Some studies suggest a link between uric acid levels and neurodegenerative diseases, though findings remain inconclusive.
• Diagnostic & Therapeutic Applications: Serum uric acid testing helps assess gout risk, kidney health, and metabolic disorders.

Serum uric acid is a key biomarker of metabolic and renal health, influencing disease progression, inflammation, and oxidative balance.

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